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Table of Contents

1. Understanding 3-MeO-PCMo: Chemistry and Pharmacology

   • Chemistry
   • Pharmacology

2. Dosage Guidelines

   • Threshold
   • Light
   • Common
   • Strong
   • Heavy

3. Effects of 3-MeO-PCMo

   • Physical Effects
   • Visual Effects
   • Cognitive Effects
   • Auditory Effects
   • Urinary Tract Effects

4. Potentially Dangerous Interactions

5. Legal Status

6. Frequently Asked Questions (FAQ)

Introduction

3-MeO-PCMo (4-[1-(3-methoxyphenyl)cyclohexyl]morpholine) emerges as a novel morpholine analogue of 3-MeO-PCP. This compound belongs to the arylcyclohexylamine chemical class, exhibiting properties as a dissociative NMDA receptor antagonist and a sigma receptor agonist. Despite its classification, 3-MeO-PCMo demonstrates a potency significantly lower than its predecessor, measuring less than one-tenth of that of 3-MeO-PCP.

Anesthetic Properties and Recreational Use

Upon ingestion, 3-MeO-PCMo induces a state known as "dissociative anesthesia." This characteristic makes it appealing for recreational use, leading to its prevalence as a recreational drug. The compound's accessibility has increased notably with its availability through online research chemical vendors, where it is marketed as a designer drug.

Online Availability and Sales

Online research chemical vendors have facilitated the widespread availability of 3-MeO-PCMo. Despite limited knowledge surrounding its effects and risks, its emergence as a designer drug has made it easily obtainable to consumers.

Past Research on Similar Compounds

While 3-MeO-PCMo remains relatively unexplored, previous investigations into morpholine analogues of phencyclidine offer some insights. These analogues serve as reference points for understanding potential effects and risks associated with 3-MeO-PCMo.

Through continued research and analysis, a comprehensive understanding of 3-MeO-PCMo and its implications can be achieved.

Understanding 3-MeO-PCMo: Chemistry and Pharmacology

Chemistry

3-MeO-PCMo, or 4-[1-(3-methoxyphenyl)cyclohexyl]morpholine, belongs to the arylcyclohexylamine drug class. These drugs feature a cyclohexane ring attached to an aromatic ring, with an amine group at the same location. In the case of 3-MeO-PCMo, the aryl substituent is a phenyl ring with a methoxy (CH3-O-) group at R3, linked to a six-membered cyclohexyl ring. At R1 on the cyclohexyl ring, there is an amine group, which is part of a morpholine ring as R4.

Morpholine, a six-membered heterocyclic ring, has an oxygen substituent at R1. 3-MeO-PCMo serves as a morpholine analogue to 3-MeO-PCP, which lacks an oxygen moiety in its six-membered amine ring, having a piperidine ring instead.

Pharmacology

Given the limited research on 3-MeO-PCMo, discussions regarding its pharmacology are speculative and based on its structure and subjective effects resembling other arylcyclohexylamine dissociatives like 3-MeO-PCP, PCP, and MXE. It is believed that 3-MeO-PCMo acts as an NMDA receptor antagonist. NMDA receptors facilitate electrical signal transmission between neurons in the brain and spinal column. Dissociatives such as 3-MeO-PCMo block these receptors, leading to neuronal disconnection, resulting in loss of sensation, impaired movement, and the characteristic "K-hole" associated with this substance.

Subjective Effects

Disclaimer: The following effects are based on the Subjective Effect Index (SEI), which relies on anecdotal user reports and personal analyses of contributors to PsychonautWiki. They should be approached with skepticism.

It's important to note that these effects may not occur predictably or reliably, with higher doses increasing the likelihood of experiencing the full spectrum of effects. Additionally, higher doses may lead to adverse effects, including addiction, severe injury, or even death.

Understanding 3-MeO-PCMo Dosage Guidelines

Threshold

A minimal dose, known as the threshold, for experiencing the effects of 3-MeO-PCMo is around 50 milligrams.

Light

For a mild experience, a dosage ranging between 100 to 200 milligrams is considered light.

Common

A commonly reported dosage falls within the range of 200 to 300 milligrams, providing users with moderate effects.

Strong

Those seeking a stronger experience may opt for a dosage between 300 to 400 milligrams, resulting in intensified effects.

Heavy

Dosages exceeding 400 milligrams are classified as heavy, leading to significantly potent effects. It's essential to approach such doses with caution due to the heightened risk of adverse reactions and potential harm.

Understanding the Effects of 3-MeO-PCMo: Physical, Visual, and Cognitive

Physical Effects

• Nausea: High doses of 3-MeO-PCMo may induce nausea and vomiting during the peak of the trip. Surprisingly, many users find this experience less unpleasant due to the detachment from physical senses.
• Loss of Motor Control: Gross and fine motor control, balance, and coordination are commonly impaired, particularly at higher doses. It's advisable to be seated before the onset of effects to prevent potential injury from falling.
• Perception of Bodily Lightness: Users may feel a sensation of weightlessness, as if their body is floating, encouraging physical activities, especially at low to moderate doses.
• Physical Autonomy: A sense of autonomy over bodily movements.
• Physical Euphoria: Feelings of pleasure and contentment in the body.
• Spatial Disorientation: Difficulty in perceiving one's surroundings accurately.
• Spontaneous Physical Sensations: Described as a soft, warm, pleasurable tingling sensation across the body, not limited to specific areas.
• Tactile Disconnection and Suppression: Altered tactile sensations and reduced sensitivity to touch.

Visual Effects

• Suppression: Reduction in visual clarity and acuity.
• Double Vision: Occurs at moderate to heavy doses, making reading impossible without closing one eye.
• Frame Rate Suppression: Perception of visual motion may be slowed.
• Pattern Recognition Suppression: Inability to recognize and interpret visual patterns.
• Visual Disconnection: Progresses to a state akin to the "k-hole," characterized by holes, spaces, and voids in visual perception.
• Distortions: Altered shapes, sizes, and proportions of objects.
• Perspective Distortions: Perception of distance and depth may be distorted.

Cognitive Effects

The cognitive effects of 3-MeO-PCMo include:

• Amnesia: Impaired memory formation and recall.
• Anxiety Suppression: Reduction in feelings of anxiety.
• Consciousness Disconnection: Feeling disconnected from one's surroundings or sense of self.
• Compulsive Redosing: The urge to take more of the substance.
• Conceptual Thinking: Ability to think abstractly and understand complex ideas.
• Creativity Enhancement: Increased imaginative thinking.
• Déjà Vu: Sensation of familiarity with current experiences.
• Depersonalization and Derealization: Feeling detached from oneself or the environment.
• Disinhibition: Reduced inhibitions and self-control.
• Dream Potentiation: Enhancement of dream recall and intensity.
• Existential Self-Realization: Insights into one's existence and place in the world.
• Euphoria: Feelings of intense happiness and well-being.
• Memory Suppression: Impaired ability to recall past events or information.
• Ego Death: Loss of the sense of self or identity.
• Immersion Enhancement: Heightened engagement and absorption in activities or experiences.
• Increased Music Appreciation: Heightened enjoyment and appreciation of music.
• Analysis Suppression: Difficulty in analyzing or critically evaluating information.
• Introspection: Reflective examination of one's thoughts and feelings.
• Mania: Elevated mood and energy levels.
• Time Distortion: Altered perception of time passing.
• Thought Deceleration: Slowed thought processes and mental activity.

Auditory Effects

• Suppression: Reduced clarity and intensity of auditory perception.
• Distortions: Altered pitch, tone, and timbre of sounds.
• Hallucinations: Perception of sounds that aren't present in the external environment.

Potentially Dangerous Interactions

Combining 3-MeO-PCMo with certain substances can lead to dangerous outcomes:

• Stimulants: Increased risk of anxiety, mania, and psychosis.
• Depressants: Heightened risk of respiratory depression and suffocation.
• Psychedelics: Potential for extreme psychological disturbances, such as psychosis and mania.

Urinary Tract Effects

Long-term, excessive use of 3-MeO-PCMo may lead to severe urinary tract issues, similar to those observed with ketamine and MXE, but potentially more severe. Symptoms may include urinary frequency, urgency, pressure, pain, hematuria, and incontinence.

Legal Status

The legal status of 3-MeO-PCMo varies globally. It's considered a legal grey area drug in many jurisdictions, including being accessible through online research chemical vendors. However, possession and distribution may still carry legal risks depending on local regulations. For instance:

• Germany: Controlled under the NpSG (New Psychoactive Substances Act) since July 18, 2019.
• Switzerland: Listed as a controlled substance under Verzeichnis E.
• United Kingdom: Illegal to produce, supply, or import under the Psychoactive Substance Act, effective May 26th, 2016. Simple possession is not criminalized.

Frequently Asked Questions (FAQ)

1. What is 3-MeO-PCMo?

3-MeO-PCMo, or 4-[1-(3-methoxyphenyl)cyclohexyl]morpholine, is a novel morpholine analogue of 3-MeO-PCP. It belongs to the arylcyclohexylamine drug class and is known for its dissociative effects.

2. What are the physical effects of 3-MeO-PCMo?

Physical effects may include nausea, loss of motor control, perception of bodily lightness, physical autonomy, euphoria, spatial disorientation, and tactile sensations.

3. What are the visual effects of 3-MeO-PCMo?

Visual effects may include suppression, double vision, frame rate suppression, pattern recognition suppression, visual disconnection, distortions, and perspective distortions.

4. What are the cognitive effects of 3-MeO-PCMo?

Cognitive effects may include amnesia, anxiety suppression, consciousness disconnection, compulsive redosing, conceptual thinking, creativity enhancement, euphoria, memory suppression, and introspection.

5. Are there any potentially dangerous interactions with 3-MeO-PCMo?

Yes, combining 3-MeO-PCMo with stimulants, depressants, or psychedelics can lead to adverse psychological reactions, respiratory depression, or other serious consequences.

6. What is the legal status of 3-MeO-PCMo?

The legal status of 3-MeO-PCMo varies by country. It's considered a legal grey area drug in many places, but possession and distribution may still carry legal risks depending on local regulations.