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Table of Contents

1. Introduction

   • Background on Diethyltryptamine (DET)
   • Transmethylation Hypothesis in the 1950s

2. Chemistry

   • Structure of Tryptamine Molecule
   • DET as a Tryptamine Analog
   • Analogues and Synthesis of 4-PO-DET and 4-HO-DET

3. Pharmacology

   • Speculations on DET's Pharmacology
   • 5-HT2A Partial Agonist Properties
   • Oral Activity and Comparison with DMT
   • Dosage Guidelines

4. Subjective Effects

   • Disclaimer on SEI and Anecdotal Reports
   • Physical Effects
   • Visual Effects
   • Cognitive Effects
   • Auditory Effects
   • Transpersonal Effects

5. Toxicity and Harm Potential

   • Lack of Scientific Studies and Unknown Toxic Dose
   • Anecdotal Insights and Harm Reduction Practices
   • Tolerance, Addiction, and Dynamics
   • Dangerous Interactions
   • Legal Status Internationally

6. FAQ (Frequently Asked Questions)

   • What is Diethyltryptamine (DET)?
   • How is DET related to DMT?
   • What are the potential physical effects of DET?
   • What are the visual effects associated with DET?
   • Is DET habit-forming?
   • What precautions should be taken when using DET?
   • How does DET interact with other substances?
   • What is the legal status of DET internationally?

Unraveling the Origins and Characteristics of Diethyltryptamine

Diethyltryptamine, also recognized as N,N-DET or DET, emerges as a synthetic psychedelic tryptamine closely related to the more renowned Dimethyltryptamine (DMT). Despite its intriguing structural parallels to DMT, DET remains an exceedingly rare substance with minimal historical documentation of human usage.

DET and the Transmethylation Hypothesis in the 1950s

The 1950s marked a pivotal era in the exploration of psychoactive agents, prompting researchers to consider endogenous production as a potential explanation for hallucinatory symptoms associated with certain psychiatric diseases. This conceptual framework was encapsulated in the transmethylation hypothesis.

Early Focus on Psychotomimetic Properties

In the early stages of DET research, as well as investigations into other psychedelics, scientists primarily concentrated on perceived psychotomimetic properties. The underlying theory posited that abnormal metabolites derived from endogenous chemicals like tryptamine, serotonin, and tryptophan could potentially elucidate the mechanisms behind mental disorders such as schizophrenia or psychosis.

Maintaining an emphasis on the historical context and scientific underpinnings, the exploration of DET offers a nuanced perspective on the evolution of psychedelic research and the intricate theories that have shaped our understanding of the human mind.

Chemical Complexity of Diethyltryptamine (DET)

A Tryptamine Odyssey: Structure and Analogs

Diethyltryptamine, abbreviated as DET or N,N-diethyltryptamine, stands as a synthetic indole alkaloid within the tryptamine class. The fundamental architecture of tryptamines involves a bicyclic indole heterocycle linked at R3 to an amino group through an ethyl side chain. Noteworthy within this family, DET, akin to its counterpart DMT, incorporates two ethyl groups (CH2CH3-) attached to the terminal amine RN of its tryptamine backbone. The broader tryptamine category encompasses diverse analogs, including 4-HO-DET ("ethocin").

The Synthetic Realm: DET and its Analogy to Natural Tryptamines

DET serves as an analog to the well-known tryptamine hallucinogen N,N-Dimethyltryptamine (DMT). Despite its artificial origin and absence in natural sources, DET has found a place in the synthesis of compounds like 4-PO-DET (Ethocybin) and 4-HO-DET (Ethocin). Intriguingly, these synthetic counterparts, distinct from the naturally occurring Psilocybin and Psilocin, have been linked to the mycelium of Psilocybe cubensis, resulting in the isolation of 3.3% 4-HO-DET and 0.01-0.8% 4-PO-DET.

Navigating DET's Pharmacological Landscape

Structure-Informed Speculations

The pharmacology of DET remains a subject of speculation due to limited research on the substance. Discussions in this realm primarily rely on the molecule's structure and subjective effects observed, drawing parallels to other tryptamine psychedelics such as psilocin and DMT. It is posited that DET functions as a 5-HT2A partial agonist.

DET's Orally Active Advantage

Distinguishing DET from its counterpart DMT is its oral activity. The ethyl groups in DET provide protection against the monoamine oxidase enzyme system, rendering it orally active. This contrasts with DMT, which is not orally active due to degradation by monoamine oxidase. The unique chemical makeup of DET, with ethyl groups attached to its nitrogen atom, shields it from degradation by monoamine oxidase, allowing for oral administration.

Dosage Guidelines

Understanding the dosage of DET is crucial for those exploring its effects. The following dosage ranges provide a spectrum of experiences:

• Threshold: 10 mg
• Light: 20 - 40 mg
• Common: 40 - 70 mg
• Strong: 70 - 100 mg
• Heavy: 100 mg and beyond

As the exploration of DET continues, these dosage guidelines offer a compass for those venturing into the nuanced landscape of this synthetic tryptamine.

Subjective Effects of Diethyltryptamine (DET)

Navigating the Psychedelic Landscape: A Disclaimer on Subjective Effects

Before delving into the subjective effects of Diethyltryptamine (DET), it is imperative to acknowledge that the information provided draws from the Subjective Effect Index (SEI). This index relies on anecdotal user reports and personal analyses from contributors at PsychonautWiki. As such, readers are encouraged to approach these effects with a healthy degree of skepticism, recognizing the inherent variability and subjectivity in individual experiences.

Understanding Potential Risks

Furthermore, it is crucial to note that the occurrence of these effects may not follow a predictable or reliable pattern. Higher doses are more likely to induce the full spectrum of effects, but with an increase in dose, adverse effects become more probable. These adverse effects could include addiction, severe injury, or even death. Caution and responsible use are paramount when engaging with substances like DET.

Exploring the Physical Realms: DET's Impact on the Body

A Multifaceted Physical Experience

Diethyltryptamine (DET) introduces a range of physical effects that users may encounter. These include:

• Stimulation: A heightened sense of alertness and physical energy.
• Spontaneous Physical Sensations: Unpredictable and involuntary bodily sensations.
• Increased Heart Rate: An acceleration of the heart's beats per minute.
• Increased Blood Pressure: A rise in the force exerted by circulating blood on the walls of blood vessels.
• Nausea: A feeling of discomfort or queasiness.
• Pupil Dilation: Enlargement of the pupils in response to light.

Illuminating the Visual Realm: DET's Influence on Perception

A Kaleidoscope of Visual Experiences

Diethyltryptamine (DET) unfolds a plethora of visual effects that can captivate the user's perception. These encompass:

• Enhancements: Heightened perception of visual elements.
• Colour Enhancement: Intensification and vibrancy of colors.
• Pattern Recognition Enhancement: Improved ability to discern patterns.
• Visual Acuity Enhancement: Sharpened visual clarity.
• Distortions: Alterations in the appearance of objects and space.
• Drifting: Morphing, breathing, and flowing of surfaces.
• Colour Shifting: Dynamic changes in color tones.
• Depth Perception Distortions: Altered perception of spatial dimensions.
• Perspective Distortions: Changes in the viewpoint of the observer.
• Symmetrical Texture Repetition: Replication of textures in a symmetrical manner.
• Tracers: Persistent trails following moving objects.
• After Images: Lingering images after the removal of a visual stimulus.
• Brightness Alteration: Fluctuations in the perceived intensity of light.
• Diffraction: The bending of light waves, leading to visual phenomena.
• Geometry: Perception of intricate geometric shapes.
• Hallucinatory States: Transcendence into unreal perceptual realms.
• Transformations: Objects undergoing metamorphosis.
• Internal Hallucination: Experiencing autonomous entities, settings, landscapes, and various hallucinatory scenarios and plots.

As users navigate the kaleidoscope of effects, DET offers a visually rich and dynamic experience.

Unraveling the Cognitive Tapestry: DET's Impact on the Mind

Cognitive Odyssey with Diethyltryptamine (DET)

Delving into the cognitive effects of Diethyltryptamine (DET) reveals a diverse tapestry of mental experiences, including:

• Conceptual Thinking: Enhanced ability for abstract and theoretical thought.
• Cognitive Euphoria: A state of profound mental pleasure and joy.
• Delusion: Distorted perceptions of reality.
• Emotion Enhancement: Amplification of emotional experiences.
• Immersion Enhancement: Heightened engagement and absorption in activities.
• Increased Music Appreciation: Elevated enjoyment and perception of music.
• Memory Suppression: Reduction in the recall of past experiences.
• Ego Death: Dissolution of the sense of self.
• Novelty Enhancement: Increased appreciation for novelty and uniqueness.
• Personal Bias Suppression: Diminished influence of personal biases.
• Thought Loops: Repetitive thought patterns.
• Time Distortion: Altered perception of time.

Harmonizing Auditory Realms: DET's Influence on Sound Perception

Auditory Dimensions Explored

Within the auditory realm, DET introduces both enhancements and distortions, contributing to the overall psychedelic experience. Users may encounter:

• Auditory Enhancements: Amplification and heightened perception of sounds.
• Auditory Distortions: Altered characteristics of sounds.
• Hallucinations: Perceptions of sounds not originating from external stimuli.

Transcending Self: DET's Transpersonal Effects

Infinity, Unity, and Interconnectedness

Diethyltryptamine (DET) extends beyond the individual experience to encompass transpersonal effects. These include feelings of:

• Infinity: A sense of boundlessness and vastness.
• Unity and Interconnectedness: Perceptions of oneness with the universe and interconnectedness with all existence.

As users navigate the cognitive and transpersonal dimensions, DET provides a multifaceted exploration of consciousness and perception.

Unveiling the Toxicity and Harm Potential of Diethyltryptamine (DET)

Navigating Uncharted Waters: Limited Insights on DET's Health Effects

The toxicity and long-term health implications of recreational Diethyltryptamine (DET) remain shrouded in uncertainty, primarily due to the lack of scientific studies in this realm. DET, categorized as a research chemical, has a minimal history of human usage, making it challenging to pinpoint its exact toxic dose. However, parallels with DMT, stemming from their structural similarities, lead to the presumption that DET shares a comparable toxicity profile.

Anecdotal Insights and Harm Reduction

Anecdotal reports from individuals who have experimented with DET suggest that, at low to moderate doses and with sparing usage, there are no apparent negative health effects directly linked to the substance. It is crucial to emphasize that these insights are based on personal experiences, and caution must be exercised. Independent research becomes imperative to ensure the safety of combining DET with other substances, as synergistic effects can be unpredictable.

It is strongly advised that harm reduction practices be implemented when engaging with DET, emphasizing responsible use to mitigate potential risks.

Tolerance, Addiction, and Their Enigma with DET

The Enigmatic Tolerance Dynamics

Despite the absence of formal studies, prevailing beliefs suggest that DET is not habit-forming. Paradoxically, the desire to use DET may decrease with its consumption, although individual reactions may vary.

Tolerance to DET's effects builds rapidly upon ingestion. The dissipation of this tolerance takes approximately 3 days to reduce to half and 7 days to return to baseline in the absence of further consumption. Notably, DET induces cross-tolerance with all psychedelics, meaning that the consumption of DET diminishes the effectiveness of other psychedelics.

Navigating Potential Perils: Dangerous Interactions

Cautionary Tales and Substance Interactions

A stern warning is issued regarding potential dangerous interactions when combining DET with other substances. While some psychoactive substances may be safe on their own, their dynamics can shift dramatically when combined. The following interactions are flagged:

• Lithium: Used in bipolar disorder treatment, it may intensify psychedelic effects, leading to psychosis and seizures.
• Stimulants: The combination may trigger uncontrollable anxiety, panic, thought loops, and paranoia, elevating the risk of psychosis.
• Tramadol: Known to lower seizure thresholds, this interaction may act as a trigger for seizures, especially in predisposed individuals.

Independent research, utilizing reputable sources, is crucial to verify the safety of combining DET with other substances.

International Legality: DET's Legal Status

A Global Regulatory Landscape

Internationally, DET is classified as a Schedule I substance under the Convention on Psychotropic Substances. Specific legal statuses across countries include:

• Australia: Schedule 9 controlled substance, subject to strict regulations.
• Germany: Controlled under Anlage I BtMG (Narcotics Act, Schedule I), making its possession and usage illegal without proper authorization.
• Italy: Classified as a Schedule I controlled substance.
• New Zealand: Designated as a Class A controlled substance.
• Switzerland: Recognized as a controlled substance under Verzeichnis D.
• United Kingdom: Classified as a Class A controlled substance.
• United States: Listed as a Schedule I controlled substance, indicating a high potential for abuse and no accepted medical use.

Users are urged to familiarize themselves with local laws to ensure compliance with legal regulations regarding DET.

FAQ (Frequently Asked Questions)

What is Diethyltryptamine (DET)?

Diethyltryptamine, or DET, is a synthetic indole alkaloid belonging to the tryptamine class. It is a close structural analog of Dimethyltryptamine (DMT) and is considered a psychedelic substance.

How is DET related to DMT?

DET shares structural similarities with DMT, with both being tryptamine hallucinogens. However, DET has two ethyl groups, making it orally active, unlike DMT.

What are the potential physical effects of DET?

Physical effects of DET may include stimulation, spontaneous sensations, increased heart rate, increased blood pressure, nausea, and pupil dilation.

What are the visual effects associated with DET?

Visual effects of DET encompass enhancements, distortions, and hallucinatory states, including color enhancement, pattern recognition enhancement, drifting, tracers, and internal hallucinations.

Is DET habit-forming?

While no formal studies have been conducted, DET is generally believed not to be habit-forming, and the desire to use it may decrease with use.

What precautions should be taken when using DET?

Users are strongly advised to practice harm reduction, conduct independent research, and be cautious of potential dangerous interactions when using DET.

How does DET interact with other substances?

DET may interact dangerously with substances like lithium, stimulants, and tramadol. Independent research is crucial to ensure the safety of combining DET with other substances.

What is the legal status of DET internationally?

Internationally, DET is classified as a Schedule I substance, indicating high potential for abuse and no accepted medical use. Specific legal statuses vary by country, and users should be aware of local regulations.