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Table of Contents

1. Introduction
2. Chemistry
3. Pharmacology
4. Dosage
5. Effects of Allylescaline
   • Physical Effects
   • Visual Effects
   • Cognitive Effects
   • Auditory Effects
6. Experience Reports
7. Assessing Toxicity and Harm Potential
8. Tolerance and Addiction Potential
9. Legal Status

Introduction

4-Allyloxy-3,5-dimethoxyphenethylamine, commonly known as allylescaline, is a lesser-known psychedelic compound belonging to the phenethylamine class. Structurally, it resembles mescaline and is closely related to escaline and methallylescaline. Despite its structural similarity to mescaline, allylescaline remains relatively obscure with minimal documented instances of human consumption.

History and Description

The effects of allylescaline were initially documented by Alexander Shulgin in his seminal work, PiHKAL: A Chemical Love Story. Shulgin outlined the dosage range for allylescaline as being between 20 to 35 milligrams when taken orally. Additionally, he noted that the duration of its effects typically spans from 8 to 12 hours.

Pharmacological Properties and Safety

Unfortunately, there exists scant data regarding the pharmacology, metabolism, and potential toxicity of allylescaline. Due to this lack of comprehensive understanding, it is strongly recommended that individuals exercise caution and adhere to harm reduction practices if contemplating the use of this substance.

Understanding Allylescaline: Chemistry

Chemical Structure

Allylescaline, also known as 4-allyloxy-3,5-dimethoxyphenethylamine, is categorized as a substituted phenethylamine. Its structure consists of a phenyl ring linked to an amino (-NH2) group via an ethyl chain. Notably, in allylescaline, there are two methoxy functional groups (CH3O-) attached to carbons R3 and R5 of the phenyl ring, along with an additional allyloxy group at carbon R4. This compound is considered the 4-allyloxy analog of mescaline.

Molecular Properties

The IUPAC name for allylescaline is 4-Allyloxy-3,5-dimethoxyphenethylamine, with a molecular formula of C13H19NO3 and a molecular weight of 237.29 g/mol. Allylescaline has an average mass of 237.294998 Da and a monoisotopic mass of 237.136002 Da.

Unveiling Allylescaline: Pharmacology

Mechanism of Action

Allylescaline functions as a partial agonist of the 5-HT2A receptor, which is associated with serotonergic psychedelic activity. The psychedelic effects attributed to allylescaline are thought to stem from its interaction with these 5-HT2A receptors. However, the precise mechanisms underlying these interactions and their contribution to the psychedelic experience remain poorly understood.

Potency and Activity

As the 4O-allyl homolog of mescaline, allylescaline exhibits similar binding patterns to serotonin receptors. Notably, it appears to possess significantly increased potency by weight compared to mescaline. Reported human doses for allylescaline range from 20 to 40 mg, considerably lower than the 300 to 400 mg typically required for mescaline.

Usage and Research

Allylescaline remains relatively uncommon and lacks a significant history of human usage. Despite its potential as a research compound, there is limited available data regarding its pharmacological properties, metabolism, and toxicity. Alexander Shulgin's documentation of allylescaline's effects in his book PiHKAL: A Chemical Love Story marks one of the primary sources of information on this compound.

Understanding Allylescaline Dosage

Threshold Dosage

The threshold dosage for allylescaline is reported to be around 15 mg. At this level, effects may begin to manifest, though they are typically subtle and may not be readily apparent to all individuals.

Light Dosage

A light dose of allylescaline ranges between 20 to 30 mg. At this dosage, users may experience mild psychedelic effects, such as alterations in perception, mood elevation, and enhanced sensory experiences.

Common Dosage

The common dosage range for allylescaline falls between 30 to 40 mg. At this level, users can anticipate more pronounced psychedelic effects, including visual distortions, changes in thought patterns, and heightened introspection.

Strong Dosage

A strong dose of allylescaline is considered to be between 40 to 60 mg. At this dosage range, users may experience intense psychedelic effects, with profound alterations in perception, significant visual hallucinations, and profound introspective experiences.

Heavy Dosage

A heavy dose of allylescaline exceeds 60 mg and may vary widely depending on individual tolerance and sensitivity. At this dosage, users should expect extremely potent and overwhelming psychedelic effects, including intense visual and auditory hallucinations, profound alterations in consciousness, and potential challenges in integrating the experience.

Exploring the Effects of Allylescaline

Physical Effects

• Spontaneous tactile sensations
• Increased heart rate
• Nausea
• Pupil dilation

Visual Effects

• Enhancements in perception
• Colour enhancement
• Pattern recognition enhancement
• Visual acuity enhancement
• Distortions such as drifting, colour shifting, and depth perception distortions
• Symmetrical texture repetition
• Tracers and after images
• Hallucinatory states including transformations and internal hallucinations

Cognitive Effects

• Conceptual thinking
• Cognitive euphoria
• Delusion
• Emotion enhancement
• Immersion enhancement
• Increased music appreciation
• Memory suppression
• Ego death
• Novelty enhancement
• Personal bias suppression
• Thought loops
• Time distortion
• Unity and interconnectedness

Auditory Effects

• Enhancements in perception
• Auditory distortions
• Hallucinations

Experience Reports

Currently, there are no anecdotal reports describing the effects of allylescaline within our experience index. Additional experience reports may be found on platforms such as Erowid Experience Vaults.

Assessing Toxicity and Harm Potential

The toxicity and long-term health effects of recreational allylescaline use have not been studied extensively in scientific contexts. As a research chemical with limited human usage history, the exact toxic dose remains unknown. Anecdotal evidence suggests minimal negative health effects at low to moderate doses used sparingly. However, individuals should practice caution and conduct independent research on substance combinations for safety.

Tolerance and Addiction Potential

Allylescaline is not considered habit-forming, and the desire to use it may decrease with continued use. Tolerance to its effects develops rapidly after ingestion, typically requiring about 3 days to reduce by half and 7 days to return to baseline without further consumption. Cross-tolerance with other psychedelics is observed, leading to reduced effects of all psychedelics following allylescaline consumption.

Legal Status

Allylescaline is subject to legal restrictions in various countries:

• Germany: Controlled under Anlage I BtMG (Narcotics Act, Schedule I).
• Japan: Classified as a controlled substance effective March 25th, 2015.
• Sweden: Illegal as of January 2016.
• Switzerland: Controlled under Verzeichnis E.
• United Kingdom: Illegal under the Psychoactive Substance Act since May 26th, 2016.

Frequently Asked Questions (FAQ)

1. What is allylescaline?

Allylescaline, also known as 4-allyloxy-3,5-dimethoxyphenethylamine, is a lesser-known psychedelic compound belonging to the phenethylamine class.

2. How does allylescaline compare to mescaline?

Allylescaline is a structural analog of mescaline, featuring an additional allyloxy group. It is considered to have increased potency by weight compared to mescaline.

3. What are the common doses of allylescaline?

Common doses of allylescaline range from 30 to 40 mg, with threshold doses starting at around 15 mg and strong doses ranging from 40 to 60 mg.

4. What are the effects of allylescaline?

Allylescaline can produce a range of effects including physical sensations, visual distortions, cognitive enhancements, and auditory hallucinations. These effects may vary depending on dosage and individual sensitivity.

5. Is allylescaline habit-forming?

Allylescaline is not considered habit-forming, and the desire to use it may decrease with continued use.

6. What is the legal status of allylescaline?

The legal status of allylescaline varies by country. It is controlled or illegal in several countries including Germany, Japan, Sweden, Switzerland, and the United Kingdom.

7. Are there any reported toxicity or harm potential associated with allylescaline use?

The toxicity and long-term health effects of allylescaline have not been extensively studied. Anecdotal evidence suggests minimal negative health effects at low to moderate doses used sparingly. However, individuals should practice caution and conduct independent research on substance combinations for safety.