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Table of Contents

1. Overview of 25N-NBOMe
2. Chemistry
   1. Chemical Background
   2. Discovery
3. Pharmacology
   1. Receptor Interaction
   2. Lack of Research
4. Effects
   1. Subjective Effects
      1. Physical Effects
      2. Visual Effects
      3. Cognitive Effects
      4. Auditory Effects
      5. Multi-Sensory Effects
      6. Transpersonal Effects
   2. Experience Reports
5. Dosage
6. Safety and Risks
   1. Toxicity and Harm Potential
   2. Tolerance and Addiction Potential
   3. Overdose
   4. Dangerous Interactions
7. Legal Status
   1. International Legal Status

Introduction to 25N-NBOMe

25N-NBOMe, also known as 2C-N-NBOMe, NBOMe-2C-N, and colloquially referred to as N-Bomb (a term used broadly for the entire 25x-NBOMe family), is a novel psychedelic substance. It belongs to the phenethylamine chemical class and produces stimulating psychedelic effects when administered.

Chemical Background

The name 25N-NBOMe is shorthand for 2C-N-NBOMe, indicating it is a derivative of the phenethylamine psychedelic 2C-N. This substance was first discovered in 2004 by Ralf Heim at the Free University of Berlin. It was later investigated by a research team at Purdue University, led by David E. Nichols.

Pharmacology and Effects

Duration and Dosage

25N-NBOMe has a notably shorter duration compared to other substances in the 25x-NBOMe series. The total duration of its effects is approximately 6 hours, with a peak duration of about 2 hours. It is moderately active at a dose of one milligram, and a dose of two milligrams can induce a strong to heavy psychedelic experience.

Potency Comparison

When compared to more popular NBOMe compounds such as 25B-NBOMe, 25I-NBOMe, and 25C-NBOMe, 25N-NBOMe is considerably less potent. The aforementioned compounds produce strong effects at doses above 1mg, whereas 25N-NBOMe requires a slightly higher dose for similar effects.

Administration

NBOMe compounds, including 25N-NBOMe, are not orally active. They must be administered sublingually. This involves placing the substance under the tongue and holding it in the mouth to allow absorption over a period of 15-25 minutes.

History and Usage

Human Use

Before 2010, 25N-NBOMe had no documented history of human use. It emerged in the market as a designer drug sold online, marking the beginning of its human application.

Safety and Risks

Extremely little is known about the pharmacological properties, metabolism, and toxicity of 25N-NBOMe in humans. Similar compounds in the 25x-NBOMe series have been linked to deaths and hospitalizations. The substance is known for its highly sensitive dose-response and unpredictable effects, making it challenging to use safely.

Harm Reduction

Due to the potential risks and lack of comprehensive understanding, it is highly advised to approach 25N-NBOMe with caution. Employing harm reduction practices is crucial if choosing to use this poorly understood psychedelic substance.

Chemical Background

The name 25N-NBOMe is shorthand for 2C-N-NBOMe, indicating it is a derivative of the phenethylamine psychedelic 2C-N. This substance was first discovered in 2004 by Ralf Heim at the Free University of Berlin. It was later investigated by a research team at Purdue University, led by David E. Nichols.

Pharmacology and Effects

Duration and Dosage

25N-NBOMe has a notably shorter duration compared to other substances in the 25x-NBOMe series. The total duration of its effects is approximately 6 hours, with a peak duration of about 2 hours. It is moderately active at a dose of one milligram, and a dose of two milligrams can induce a strong to heavy psychedelic experience.

Dosage Guidelines

• Threshold: < 100 µg
• Light: 100 - 300 µg
• Common: 300 - 800 µg
• Strong: 800 - 1300 µg
• Heavy: > 1300 µg

It is important to note that the NBOMe series can be fatal at heavy doses.

Potency Comparison

When compared to more popular NBOMe compounds such as 25B-NBOMe, 25I-NBOMe, and 25C-NBOMe, 25N-NBOMe is considerably less potent. The aforementioned compounds produce strong effects at doses above 1mg, whereas 25N-NBOMe requires a slightly higher dose for similar effects.

Administration

NBOMe compounds, including 25N-NBOMe, are not orally active. They must be administered sublingually. This involves placing the substance under the tongue and holding it in the mouth to allow absorption over a period of 15-25 minutes.

History and Usage

Human Use

Before 2010, 25N-NBOMe had no documented history of human use. It emerged in the market as a designer drug sold online, marking the beginning of its human application.

Safety and Risks

Extremely little is known about the pharmacological properties, metabolism, and toxicity of 25N-NBOMe in humans. Similar compounds in the 25x-NBOMe series have been linked to deaths and hospitalizations. The substance is known for its highly sensitive dose-response and unpredictable effects, making it challenging to use safely.

Harm Reduction

Due to the potential risks and lack of comprehensive understanding, it is highly advised to approach 25N-NBOMe with caution. Employing harm reduction practices is crucial if choosing to use this poorly understood psychedelic substance.

Chemistry

Chemical Background

25N-NBOMe or 2C-N-NBOMe is a serotonergic N-benzyl derivative of the substituted phenethylamine psychedelic known as 2C-N. It is a substituted phenethylamine with methoxy groups (CH3O-) attached to carbons R2 and R5, as well as a nitro group (NO2-) attached to carbon R4. It differs from 2C-N structurally through a substitution on the amine (NH2) with a 2-methoxybenzyl (BOMe) group. This NBOMe addition contains a methoxy ether (CH3O-) bound to a benzene ring at R2.

Discovery

This substance was first discovered in 2004 by Ralf Heim at the Free University of Berlin and was later investigated by a research team at Purdue University, led by David E. Nichols.

Pharmacology

Receptor Interaction

25N-NBOMe likely has efficacy at the 5-HT2A receptor, where it is assumed to act as a partial agonist. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

Lack of Research

There is insufficient scientific research to determine this compound's true nature, as the pharmacological properties of 25N-NBOMe have not been described in the scientific literature, but only in anecdotal reports.

Effects

Subjective Effects

The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. These effects may not occur in a predictable or reliable manner. Higher doses are more liable to induce the full spectrum of effects, while adverse effects become increasingly likely.

Physical Effects

• Stimulation: Typically very energetic and stimulating, but controllable for most users. Some may experience uncontrollable stimulation, resulting in bodily shakes and teeth grinding.
• Perception of Bodily Lightness: Users often feel extremely light, sometimes to the point of total weightlessness.
• Spontaneous Physical Sensations: Mild, euphoric tingling sensations that can become more pronounced with higher doses.
• Physical Euphoria
• Tactile Enhancement
• Bodily Control Enhancement: When combined with stimulation, this manifests as a strong drive to partake in physical activities.
• Mouth Numbing: A strong, unpleasant metallic chemical taste and numbness in the mouth immediately after sublingual absorption.
• Abnormal Heartbeat
• Increased Heart Rate
• Increased Blood Pressure
• Muscle Contractions, Cramps, and Tension
• Gustatory Hallucinations
• Nausea: Especially during the come-up, subsiding over the peak.
• Appetite Suppression
• Runny Nose
• Stomach Cramps
• Dehydration and Dry Mouth
• Difficulty Urinating or Frequent Urination
• Restless Legs
• Pupil Dilation
• Headaches
• Seizures

Visual Effects

• Enhancements: Visual acuity, color enhancement, pattern recognition.
• Distortions: Drifting, melting, flowing, breathing, and morphing effects. Highly detailed, slow, and smooth in motion.
• Geometry: Algorithmic, intricate, fine, structured, colorful, glossy, and mostly rounded visual geometry.
• Hallucinatory States: Transformations and internal hallucinations, including autonomous entities, settings, and scenarios.

Cognitive Effects

• Analysis Enhancement
• Thought Acceleration and Deceleration
• Conceptual Thinking
• Anxiety and Paranoia
• Empathy, Affection, and Sociability Enhancement
• Memory Suppression
• Ego Death
• Amnesia
• Novelty Enhancement
• Immersion Enhancement
• Emotion Enhancement
• Increased Sense of Humor
• Laughter Fits
• Increased Music Appreciation
• Personal Bias Suppression
• Increased Libido
• Time Distortion
• Wakefulness

Auditory Effects

• Enhancements
• Distortions
• Hallucinations

Multi-Sensory Effects

• Dosage Independent Intensity
• Synaesthesia

Transpersonal Effects

• Existential Self-Realization
• Unity and Interconnectedness

Experience Reports

There are currently no anecdotal reports which describe the effects of this compound within the experience index. Additional experience reports can be found in the Erowid Experience Vaults.

Dosage

• Threshold: < 100 µg
• Light: 100 - 300 µg
• Common: 300 - 800 µg
• Strong: 800 - 1300 µg
• Heavy: > 1300 µg

The NBOMe series can be fatal at heavy doses.

Safety and Risks

Toxicity and Harm Potential

The toxicity and long-term health effects of recreational 25N-NBOMe use have not been studied in any scientific context, and the exact toxic dosage is unknown. Users should be cautious, as ingesting 2mg+ of NBOMe series chemicals has proven fatal in some cases. Although there are no reported deaths caused by 25N-NBOMe at this time, it is a rare research chemical with very little history of human usage and is therefore potentially fatal at heavy dosages.

Tolerance and Addiction Potential

25N-NBOMe is not habit-forming, and the desire to use it can decrease with use. Tolerance to its effects builds almost immediately after ingestion, reducing to half after 3 days and back to baseline in 7 days. It presents cross-tolerance with all psychedelics.

Overdose

The margin between a normal and an overdose of NBOMe compounds is extremely small. Dangerous side effects may appear when exceeding 1000 µg and can be potentially lethal at around 2000 µg for sensitive individuals. Overdose effects include dangerously high heart rate, blood pressure, hyperthermia, vasoconstriction, confusion, delusions, panic attacks, aggressive behavior, numbness, pain, amnesia, and seizures.

Dangerous Interactions

Many psychoactive substances can become dangerous when combined with NBOMe compounds. Known dangerous interactions include:

• 2C-T-X Phenethylamines
• 5-MeO Tryptamines
• Amphetamines
• Caffeine
• Cannabis
• Cocaine
• DOx
• DXM
• Lithium
• MAOIs
• MDMA
• MXE
• Tramadol

Legal Status

International Legal Status

• Austria: Illegal under NPSG.
• Brazil: Illegal under Portaria SVS/MS nº 344.
• Germany: Controlled under Anlage I BtMG as of June 9, 2016.
• Latvia: Schedule I controlled substance.
• Switzerland: Controlled under Verzeichnis E.
• United Kingdom: Class A drug under the N-benzylphenethylamine catch-all clause.
• United States: Unscheduled, but may be considered an analogue of 2C-N, making it potentially prosecutable under the Federal Analogue Act.

FAQ

What is 25N-NBOMe?

25N-NBOMe, also known as 2C-N-NBOMe, is a serotonergic N-benzyl derivative of the substituted phenethylamine psychedelic 2C-N. It produces stimulating psychedelic effects and belongs to the phenethylamine chemical class.

What are the chemical properties of 25N-NBOMe?

25N-NBOMe has methoxy groups attached to carbons R2 and R5, and a nitro group attached to carbon R4. It differs from 2C-N by a substitution on the amine with a 2-methoxybenzyl group.

How does 25N-NBOMe interact with the brain?

It likely has efficacy at the 5-HT2A receptor and acts as a partial agonist, but its pharmacological properties are not well understood due to a lack of scientific research.

What are the physical effects of 25N-NBOMe?

Physical effects can include stimulation, perception of bodily lightness, spontaneous physical sensations, physical euphoria, tactile enhancement, mouth numbing, increased heart rate, and more.

What are the visual effects of 25N-NBOMe?

Visual effects can include visual acuity enhancement, color enhancement, pattern recognition enhancement, and various visual distortions such as drifting, melting, and symmetrical texture repetition.

What are the cognitive effects of 25N-NBOMe?

Cognitive effects can include analysis enhancement, thought acceleration and deceleration, conceptual thinking, anxiety and paranoia, empathy enhancement, memory suppression, ego death, and more.

What is the recommended dosage for 25N-NBOMe?

• Threshold: < 100 µg
• Light: 100 - 300 µg
• Common: 300 - 800 µg
• Strong: 800 - 1300 µg
• Heavy: > 1300 µg

What are the risks associated with 25N-NBOMe?

Risks include potential toxicity, overdose, dangerous side effects, and the unpredictability of effects. It is crucial to use harm reduction practices.

What is the legal status of 25N-NBOMe?

25N-NBOMe is illegal in many countries, including Austria, Brazil, Germany, Latvia, Switzerland, the United Kingdom, and may be considered an analogue of 2C-N in the United States.

What should be done in case of an overdose?

In case of an overdose, seek immediate medical attention. Symptoms can include dangerously high heart rate, blood pressure, hyperthermia, vasoconstriction, confusion, delusions, panic attacks, aggressive behavior, numbness, pain, amnesia, and seizures.

Can 25N-NBOMe be mixed with other substances?

Mixing 25N-NBOMe with other psychoactive substances is generally not advised due to the unpredictable nature of its interactions, which can become dangerous or life-threatening.