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Table of Contents

1. Introduction

   • Background of 4-HO-DiPT
   • Chemical Structure and Related Compounds

2. Chemistry

   • Molecular Structure of 4-HO-DiPT
   • Relationship with DiPT and 4-HO-DMT
   • Pharmacological Insights

3. Dosage

   • Threshold
   • Light
   • Common
   • Strong
   • Heavy

4. Subjective Effects

   • Disclaimer
   • Overview of Cognitive, Visual, Auditory, Physical, Sensory, Emotional, and Transpersonal Effects

5. Physical Effects

   • Stimulation
   • Spontaneous Physical Sensations
   • Cardiovascular Effects
   • Nausea
   • Pupil Dilation
   • Visual Effects (Enhancements, Distortions, Hallucinatory States)
   • Cognitive Effects
   • Auditory Effects
   • Transpersonal Effects

6. Toxicity and Harm Potential

   • Lack of Scientific Studies
   • Anecdotal Reports
   • Harm Reduction Practices
   • Tolerance and Addiction Potential
   • Dangerous Interactions
   • Legal Status

Introduction

4-Hydroxy-N,N-diisopropyltryptamine, commonly known as 4-HO-DiPT or Iprocin, is a psychedelic substance belonging to the tryptamine class. Similar to psilocin, it induces psychedelic effects upon administration. Structurally, it is the 4-hydroxy analog of DiPT and shares similarities with other tryptamines like 4-HO-DMT (Psilocin), 4-HO-MiPT (Miprocin), and 4-HO-DET (Ethocin).

Exploration of Effects

First synthesized by David B. Repke in 1977, the effects of 4-HO-DiPT in humans were further investigated by Alexander Shulgin. Shulgin detailed its characteristics in his 1997 book "TiHKAL" ("Tryptamines I Have Known and Loved"). Notably, it stands out among psychedelics due to its unique properties: rapid onset (typically within 15 minutes of ingestion), intense effects (even 20 milligrams can induce transcendent experiences), short duration (lasting 2-3 hours), and sensitivity to dosage. Users also reported idiosyncratic physical effects such as muscle tremors and bodily discomfort.

Current Usage and Distribution

Today, 4-HO-DiPT is used for both recreational and entheogenic purposes. However, it remains relatively uncommon and is occasionally available on the online research chemical market. Despite its usage, there is limited knowledge about its pharmacological properties, metabolism, and toxicity in humans, partly due to its restricted history of human consumption. Given these uncertainties, it is strongly advised to practice harm reduction measures when using this substance.

Chemistry of 4-HO-DiPT

4-HO-DiPT, also known as 4-Hydroxy-N,N-diisopropyltryptamine, is a synthetic indole alkaloid belonging to the tryptamine chemical class. Tryptamines share a fundamental structure characterized by a bicyclic indole heterocycle attached at R3 to an amino group through an ethyl side chain. In the case of 4-HO-DiPT, it is further distinguished by a hydroxyl functional group (OH−) at R4 of its indole heterocycle and two isopropyl groups attached to the terminal amine RN of its tryptamine backbone.

Relationship with DiPT and 4-HO-DMT

4-HO-DiPT serves as a 4-hydroxy analog of DiPT and represents the N-substituted isopropyl homolog of 4-HO-DMT.

Pharmacology

Serotonergic Psychedelic Properties

Like many psychedelic tryptamines, 4-HO-DiPT is primarily believed to act as a 5-HT2A partial agonist. The psychedelic effects associated with 4-HO-DiPT are thought to stem from its binding efficacy at the 5-HT2A receptors. However, the precise mechanisms of these interactions and how they contribute to the psychedelic experience remain elusive. Further research is needed to fully understand the pharmacological properties of 4-HO-DiPT and its impact on the serotonergic system.

Dosage of 4-HO-DiPT

Understanding the appropriate dosage of 4-HO-DiPT is crucial for safe and responsible use of this psychedelic substance. The following dosage guidelines provide a framework for users to gauge the intensity of their experience.

Threshold Dosage

The threshold dosage for 4-HO-DiPT is noted at 3 mg. At this level, users may start to perceive subtle effects, marking the beginning of the psychedelic experience.

Light Dosage

In the light dosage range of 3 to 10 mg, users can expect a mild to moderate experience. This dosage is suitable for those seeking a gentle introduction to the effects of 4-HO-DiPT, with perceptual changes and a mild alteration of consciousness.

Common Dosage

The common dosage range falls between 10 and 20 mg. At this level, users can anticipate a more pronounced and immersive psychedelic experience. It is a suitable range for those familiar with 4-HO-DiPT and seeking a moderate to strong effect.

Strong Dosage

For a stronger psychedelic encounter, individuals may choose a dosage between 20 and 30 mg. This range is characterized by intensified effects, potentially leading to a more profound and transformative experience.

Heavy Dosage

Dosages exceeding 30 mg are considered heavy. At this level, users should be prepared for a significantly intense and immersive psychedelic journey. Heavy dosages of 4-HO-DiPT may induce profound alterations in perception and consciousness.

It is essential for users to approach 4-HO-DiPT with caution and adhere to harm reduction practices. Understanding individual tolerance and sensitivity is crucial, and users are encouraged to start with lower doses before gradually increasing if needed. Additionally, having a trusted and sober companion can contribute to a safer and more positive experience.

Subjective Effects of 4-HO-DiPT

Understanding the subjective effects of 4-HO-DiPT is essential for individuals considering its use. However, it is crucial to approach the information with a degree of skepticism, as the effects can vary among users. The Subjective Effect Index (SEI) serves as a reference, relying on anecdotal user reports and analyses from contributors to PsychonautWiki.

Disclaimer

Before delving into the subjective effects, it is important to acknowledge the limitations of the SEI. The information is based on open research literature and anecdotal experiences, which may not guarantee predictability or reliability in individual cases. Higher doses are more likely to induce a full spectrum of effects, but adverse reactions, including addiction, severe injury, or death, become increasingly probable with elevated doses.

Subjective Effects Overview

1. Cognitive Effects

   • Thought Acceleration
   • Conceptual Thinking
   • Time Distortion
   • Novelty Enhancement

2. Visual Effects

   • Enhancements
   • Distortions
   • Hallucinations (at higher doses)

3. Auditory Effects

   • Enhancements
   • Distortions

4. Physical Effects

   • Spontaneous Body Sensations
   • Tactile Enhancement
   • Motor Control Loss (at higher doses)

5. Sensory Effects

   • Intensified Taste and Smell

6. Emotional Effects

   • Euphoria
   • Anxiety
   • Empathy Enhancement

7. Transpersonal Effects

   • Unity and interconnectedness (at higher doses)

Individual reactions to 4-HO-DiPT can vary, and the SEI provides a general overview based on reported experiences. Users are advised to exercise caution, particularly with higher doses, as adverse effects become more likely. It is crucial to prioritize safety, adhere to harm reduction practices, and be aware of potential risks associated with the use of 4-HO-DiPT.

Physical Effects of 4-HO-DiPT

Understanding the physical effects of 4-HO-DiPT is crucial for individuals considering its use. This section outlines various physical responses that users may experience, based on anecdotal reports and research.

Stimulation

4-HO-DiPT is known to induce a sense of stimulation, contributing to increased energy levels and heightened alertness.

Spontaneous Physical Sensations

Users may encounter spontaneous physical sensations, such as tingling or waves of energy passing through the body.

Cardiovascular Effects

The substance can lead to increased heart rate and elevated blood pressure, potentially impacting individuals with pre-existing cardiovascular conditions.

Nausea

Nausea is a common physical side effect associated with 4-HO-DiPT use, particularly during the onset of the experience.

Pupil Dilation

Pupil dilation is a notable physiological response to 4-HO-DiPT, leading to enlarged pupils.

Visual Effects

Enhancements

• Colour Enhancement: Colors may appear more vibrant and intense.
• Pattern Recognition Enhancement: Improved ability to perceive and recognize patterns.
• Visual Acuity Enhancement: Heightened visual clarity.

Distortions

• Drifting (Melting, Breathing, Morphing, and Flowing): Static objects may appear to move or change shape.
• Colour Shifting: Colors may undergo dynamic changes.
• Depth Perception Distortions: Altered perception of spatial depth.
• Perspective Distortions: Changes in the perception of distances and proportions.
• Symmetrical Texture Repetition: Patterns may repeat symmetrically.
• Tracers: Persistent trails following moving objects.
• After Images: Lingering visual impressions after exposure to stimuli.
• Brightness Alteration: Fluctuations in the perceived brightness of the environment.
• Diffraction: Visual phenomena related to the bending of light.

Hallucinatory States

• Transformations: Objects may undergo profound changes.

Internal Hallucination

• Autonomous Entities: Perception of independent, hallucinated beings.
• Settings, Sceneries, and Landscapes: Vivid internal visual landscapes.
• Perspective Hallucinations and Scenarios: Altered perceptions of space and imagined scenarios.
• Plots: Narratives or storylines experienced internally.

Cognitive Effects

Refer to the "Cognitive Effects" section for a detailed exploration of cognitive responses associated with 4-HO-DiPT.

Auditory Effects

Refer to the "Auditory Effects" section for a detailed exploration of auditory responses associated with 4-HO-DiPT.

Transpersonal Effects

Unity and Interconnectedness

At higher doses, users may report experiencing a sense of unity and interconnectedness with the surroundings, a common phenomenon in the realm of psychedelic experiences.

Toxicity and Harm Potential of 4-HO-DiPT

The toxicity and long-term health effects of recreational 4-HO-DiPT use have not been scientifically studied due to its status as a research chemical with minimal human usage history. This article aims to provide an overview of potential harm and safety considerations based on anecdotal reports.

Lack of Scientific Studies

As of now, there is no scientific context for studying the toxicity or long-term health effects of 4-HO-DiPT. The exact toxic dose remains unknown, and caution is advised due to its limited history of human usage.

Anecdotal Reports

Anecdotal reports from individuals who have tried 4-HO-DiPT suggest that at low to moderate doses, used sparingly, there are no notable negative health effects. However, it is essential to recognize that individual reactions can vary, and nothing can be entirely guaranteed.

Harm Reduction Practices

To mitigate potential risks, it is strongly recommended to employ harm reduction practices when using 4-HO-DiPT. Independent research should be conducted to ensure the safety of combining it with other substances.

Tolerance and Addiction Potential

4-HO-DiPT is not considered habit-forming, and the desire to use it may decrease with regular consumption. Tolerance to its effects develops almost immediately after ingestion, taking approximately 3 days for a 50% reduction and 7 days to return to baseline in the absence of further consumption. Cross-tolerance with other psychedelics is reported, meaning a reduced effect after consuming 4-HO-DiPT.

Dangerous Interactions

Warning

Combining 4-HO-DiPT with certain substances can be dangerous or life-threatening. Known dangerous interactions include:

• Lithium: Increased risk of psychosis and seizures, particularly dangerous for those with bipolar disorder.
• Cannabis: Unpredictable synergy with 4-HO-DiPT, potentially increasing the risk of adverse psychological reactions.
• Stimulants: Elevated risk of anxiety, paranoia, panic attacks, thought loops, mania, and psychosis.
• Tramadol: May lower the seizure threshold, potentially triggering seizures in susceptible individuals.

Always conduct independent research to ensure the safety of combining 4-HO-DiPT with other substances.

Legal Status

The legal status of 4-HO-DiPT varies by country:

• Germany: Controlled under the NpSG (New Psychoactive Substances Act).
• Sweden: Classified as a "health hazard," making it illegal to sell or possess.
• Switzerland: Not controlled under specific categories, potentially considered legal.
• United Kingdom: Class A drug due to the tryptamine catch-all clause.
• United States: Unscheduled but could be considered an analogue of psilocin, a Schedule I drug.
• Florida (USA): Schedule I controlled substance, illegal to buy, sell, or possess.

FAQ (Frequently Asked Questions)

Q1: Is 4-HO-DiPT habit-forming?

No, 4-HO-DiPT is not considered habit-forming, and the desire to use it may decrease with regular consumption.

Q2: How quickly does tolerance develop after ingesting 4-HO-DiPT?

Tolerance to the effects of 4-HO-DiPT develops almost immediately after ingestion. It takes about 3 days for the tolerance to be reduced by 50% and 7 days to return to baseline in the absence of further consumption.

Q3: Are there any known dangerous interactions with 4-HO-DiPT?

Yes, some substances can have dangerous interactions with 4-HO-DiPT. These include lithium, cannabis, stimulants, and tramadol. Always conduct independent research to ensure the safety of combining 4-HO-DiPT with other substances.

Q4: What is the legal status of 4-HO-DiPT in different countries?

The legal status of 4-HO-DiPT varies by country. For example, it is unscheduled in the United States but controlled in Germany under the NpSG and classified as a "health hazard" in Sweden.

Q5: Are there any long-term health effects associated with 4-HO-DiPT use?

As of now, there are no scientific studies on the long-term health effects of 4-HO-DiPT due to its limited human usage history. Anecdotal reports suggest no negative health effects at low to moderate doses, but caution is advised.