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Table of Contents

1. Introduction

   • Overview of 25C-NBOH
   • History and Synthesis

2. Chemistry

   • Chemical Structure
   • Pharmacology
   • Receptor Affinity

3. Subjective Effects

   • Physical Effects
   • Visual Effects
   • Cognitive Effects
   • Auditory Effects
   • Multi-sensory Effects
   • Transpersonal Effects

4. Toxicity and Harm Potential

   • Risks and Concerns
   • Tolerance and Addiction Potential
   • Dangerous Interactions

5. Legal Status

6. FAQ (Frequently Asked Questions)

Understanding 25C-NBOH: A Novel Synthetic Psychedelic

Introduction to 25C-NBOH

25C-NBOH, also referred to as 2C-C-NBOH and NBOH-2C-C, is an emerging synthetic psychedelic compound belonging to the phenethylamine chemical class. This substance induces a range of visually dominant and stimulating psychedelic effects upon administration. Similar to its counterpart, 25B-NBOMe, it shares most properties, albeit with a slightly reduced potency and shorter duration.

Origins and Synthesis

The nomenclature 25C-NBOH stems from its association with 2C-C, a well-known phenethylamine psychedelic. Martin Hansen, based at the University of Copenhagen, first synthesized and documented this compound in 2011, marking its initial introduction into scientific discourse.

Administration and Consumption

It's essential to note that members of the NBOH family, including 25C-NBOH, are not orally active. The recommended method of consumption involves sublingual administration. Users are advised to place the substance under the tongue and hold it there for 15-25 minutes, allowing for absorption.

Pharmacological Properties and Safety Concerns

Despite its growing popularity, there remains a dearth of knowledge regarding the pharmacological properties, metabolism, and toxicity of 25C-NBOH in humans. Prior to its emergence as a designer drug in 2011, it lacked any documented history of human use. This lack of data is concerning, especially given its close relation to the 25x-NBOMe series, which has been linked to numerous hospitalizations and fatalities.

Anecdotal reports hint at the challenges associated with safely using 25C-NBOH. Its highly sensitive dose-response curve and unpredictable effects underscore the importance of cautious and informed consumption practices.

Understanding Dosage of 25C-NBOH

Threshold Dosage

The threshold dosage for 25C-NBOH, the minimum amount required to elicit any noticeable effects, is reported to be 100 µg.

Light Dosage

At light doses, users typically experience subtle effects. The range for light dosage falls between 250 to 500 µg.

Common Dosage

A common dosage of 25C-NBOH typically induces moderate psychedelic effects. This range extends from 500 to 750 µg.

Strong Dosage

At strong doses, the psychedelic effects of 25C-NBOH become pronounced. This range varies between 750 to 1000 µg.

Heavy Dosage

Heavy doses of 25C-NBOH can be exceptionally dangerous, potentially leading to fatal consequences. It is advised to avoid doses exceeding 1000 µg due to the heightened risk of severe adverse reactions and even death.

Unveiling the Chemistry of 25C-NBOH

Chemical Structure

25C-NBOH, also known as 2C-C-NBOH, belongs to the serotonergic N-benzyl derivatives of the substituted phenethylamine psychedelic 2C-C. Structurally, it is a substituted phenethylamine featuring methoxy groups (CH3O-) attached to carbons R2 and R5, as well as a bromine atom attached to carbon R4. The distinctive modification distinguishing it from 2C-C is the substitution on the amine (NH2) with a 2-hydroxybenzyl (BOH) group. This shared 2-hydroxybenzyl substitution characterizes other members of the NBOH family, consisting of a hydroxy ether (OH-) bound to a benzene ring at R2.

Unraveling the Pharmacology of 25C-NBOH

Receptor Affinity

25C-NBOH primarily targets the 5-HT2A receptor, where it acts as a potent agonist. Its pharmacological uniqueness lies in its exceptionally high selectivity for various serotonin receptors. Notably, it ranks among the most selective agonist ligands for the 5-HT2A receptor, boasting a pEC50 value of 9.43. Additionally, it acts as a potent serotonin receptor agonist, exhibiting similar affinity to the well-known compound 25C-NBOMe at 5-HT2A and 5-HT2C receptors, with pKis values of 9.4 and 7.8, respectively. However, the precise mechanisms through which these interactions translate into the psychedelic experience remain largely elusive.

Subjective Effects

Physical Effects

• Stimulation: Users commonly experience a high level of physical energy, described as extremely energetic yet not necessarily inducing involuntary movement.
• Perception of Bodily Lightness: Users often report feeling unusually light, sometimes to the point of total weightlessness.
• Spontaneous Physical Sensations: A mild, euphoric tingling sensation accompanied by rushes of euphoria is frequently reported.
• Mouth Numbing: Sublingual administration is marked by a strong metallic taste and numbness in the tongue and mouth.
• Nausea: Initial nausea may occur during the onset but typically diminishes as the trip progresses. 

• Temperature Regulation Suppression
• Increased Bodily Temperature
• Abnormal Heartbeat
• Increased Heart Rate
• Increased Blood Pressure
• Muscle Contractions
• Muscle Cramps
• Muscle Tension
• Gustatory Hallucination
• Vasoconstriction
• Appetite Suppression
• Stomach Cramps
• Dehydration
• Dry Mouth
• Difficulty Urinating or Frequent Urination
• Restless Legs
• Pupil Dilation
• Headaches
• Seizures

Visual Effects

• Enhancements: Visual acuity, color, and pattern recognition.
• Distortions: Drifting, color shifting, depth perception distortions, etc.
• Geometry: Intricate, algorithmic patterns, similar to LSD.
• Hallucinatory States: Transformations, machinescapes, internal hallucinations, etc.

Cognitive Effects

• Analysis Enhancement
• Thought Acceleration
• Conceptual Thinking
• Anxiety & Paranoia
• Feelings of Impending Doom
• Empathy, Affection, and Sociability Enhancement
• Memory Suppression
• Ego Death
• Amnesia
• Novelty Enhancement
• Immersion Enhancement
• Emotion Enhancement
• Increased Sense of Humor
• Laughter Fits
• Increased Music Appreciation
• Personal Bias Suppression
• Increased Libido
• Time Distortion
• Wakefulness

Auditory Effects

• Auditory Enhancement
• Auditory Distortion
• Auditory Hallucination

Multi-sensory Effects

• Dosage Independent Intensity
• Synaesthesia

Transpersonal Effects

• Existential Self-Realization
• Unity and Interconnectedness

Toxicity and Harm Potential

25C-NBOH's toxicity and potential for harm are areas of concern due to its novelty and limited research. Similar to other substances in the 25x-NBOMe series, it is presumed to pose acute health risks, potentially leading to fatalities at heavy doses. Insufflation (snorting) is particularly dangerous, associated with numerous deaths and hospitalizations. However, further research is required to determine its exact LD50 and long-term effects.

Tolerance and Addiction Potential

While 25C-NBOH is not considered habit-forming, tolerance to its effects develops rapidly after ingestion. Cross-tolerance with other psychedelics is observed, necessitating caution with subsequent use to avoid diminished effects.

Dangerous Interactions

Combining 25C-NBOH with certain substances can pose significant risks, including psychosis, seizures, anxiety, and paranoia. Caution is advised, particularly when using it in conjunction with lithium, cannabis, stimulants, tramadol, or other psychoactive compounds.

Legal Status

The legal status of 25C-NBOH varies by country. For example, it is classified as a controlled substance in countries like Brazil, Germany, Sweden, and Switzerland. In the United Kingdom, it is designated as a Class A drug.

FAQ (Frequently Asked Questions)

Q: What is 25C-NBOH?

A: 25C-NBOH, also known as 2C-C-NBOH, is a synthetic psychedelic compound belonging to the phenethylamine chemical class. It induces a range of visually dominant and stimulating psychedelic effects upon administration.

Q: How is 25C-NBOH synthesized?

A: 25C-NBOH is synthesized from 2C-C through a series of chemical reactions, typically involving substitutions and modifications on the phenethylamine structure.

Q: What are the common dosage ranges for 25C-NBOH?

A: The common dosage ranges for 25C-NBOH are as follows:

• Threshold: 100 µg
• Light: 250 - 500 µg
• Common: 500 - 750 µg
• Strong: 750 - 1000 µg
• Heavy: >1000 µg (potentially fatal)

Q: What are the subjective effects of 25C-NBOH?

A: The subjective effects include a wide range of physical, visual, cognitive, and auditory alterations. These effects can vary in intensity and duration depending on the dosage and individual response.

Q: Is 25C-NBOH safe to use?

A: There are significant safety concerns associated with 25C-NBOH, including its potential for toxicity, dangerous interactions with other substances, and the risk of adverse reactions at high doses. Caution and informed decision-making are essential when considering its use.

Q: What is the legal status of 25C-NBOH?

A: The legal status of 25C-NBOH varies by country. It is classified as a controlled substance in several countries, while in others, it may be subject to specific regulations governing its production, distribution, and use.