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Table of Contents

1. Introduction
2. Chemistry
3. Pharmacology
4. Subjective Effects
5. Toxicity and Harm Potential
6. Tolerance and Addiction Potential
7. Legal Status

Proscaline: An Overview of a Lesser-Known Psychedelic Substance

Introduction

4-Propyloxy-3,5-dimethoxyphenethylamine, commonly known as proscaline, belongs to the phenethylamine class of psychedelic substances.[1] Structurally akin to mescaline, proscaline is part of a series of mescaline analogs that encompasses compounds like isoproscaline, escaline, and allylescaline.

Synthesis and Evaluation

The synthesis of proscaline was initially detailed by David E. Nichols in 1977.[2] Concurrently, Alexander Shulgin conducted trials, exploring the compound at doses reaching up to 60 mg. Shulgin's assessment suggested a potency approximately five times greater than that of mescaline.[3] His observations were later chronicled in the 1991 publication "PiHKAL" ("Phenethylamines I Have Known and Loved").

Availability and Usage

Proscaline emerged for purchase on the online research chemical market during the 2010s.[citation needed] Subjective experiences of proscaline closely resemble those of mescaline, featuring open and closed-eye visuals, time distortion, heightened introspection, conceptual thinking, euphoria, and ego dissolution. However, users commonly report milder visual effects, euphoria, and ego loss compared to mescaline. Consequently, the recreational demand for proscaline remains relatively limited. Nevertheless, its potential as an adjunct in psychedelic therapy warrants further exploration.

Pharmacology and Safety

Limited data exists regarding the pharmacological properties, metabolism, and toxicity of proscaline. While assumed to share a risk profile akin to mescaline, this hypothesis remains unverified by studies. Consequently, employing harm reduction practices is highly recommended for individuals considering the use of this substance.

Exploring Proscaline Dosage: Understanding Thresholds and Effects

Threshold Dosage

Proscaline, a member of the phenethylamine class of psychedelics, exhibits its effects at relatively low doses. The threshold dose for proscaline is noted to be around 10 mg. At this level, users may begin to perceive subtle alterations in perception and cognition.

Light Dosage

A light dose of proscaline typically ranges between 15 to 30 mg. At this level, users may experience mild visual distortions, changes in mood, and heightened sensory perception. These effects are often manageable and conducive to introspection or recreational exploration.

Common Dosage

The common dosage range for proscaline extends from 30 to 40 mg. Within this range, users typically encounter more pronounced psychedelic effects, including vivid visuals, alterations in time perception, and intensified emotional experiences. It represents a moderate yet significant psychedelic experience for most individuals.

Strong Dosage

A strong dosage of proscaline is considered to be within the range of 40 to 60 mg. At these doses, the psychedelic effects become notably intensified, potentially leading to profound perceptual shifts, ego dissolution, and profound introspection. Users should approach this dosage range with caution due to the increased intensity of effects.

Heavy Dosage

Heavy dosages of proscaline exceed 60 mg. At these doses, users may experience extremely intense psychedelic effects, including overwhelming visuals, complete ego dissolution, and profound alterations in consciousness. This dosage range is typically reserved for experienced users seeking exceptionally deep and immersive psychedelic experiences.

Understanding the dosage ranges of proscaline is crucial for safe and responsible use, ensuring that users can navigate their psychedelic experiences with awareness and caution.

Unraveling the Chemistry of Proscaline

Chemical Structure

Proscaline, scientifically termed 3,5-dimethoxy-4-propyloxyphenethylamine, belongs to the substituted phenethylamine class. It consists of a phenyl ring connected to an amino (-NH2) group via an ethyl chain. Notably, proscaline features two methoxy functional groups (CH3O-) attached to carbons R3 and R5, along with an additional propyloxy group at carbon R4 of the phenyl ring. This compound serves as the 4-propyloxy analog of mescaline, differing by one additional carbon in the alkyloxy group compared to escaline, another closely related mescaline analog.

Deciphering Proscaline's Pharmacology

Mechanism of Action

Proscaline's psychedelic effects are attributed to its interaction with the 5-HT2A receptor as a partial agonist. However, the precise mechanisms underlying these interactions and their role in eliciting the psychedelic experience remain incompletely understood.

Exploring Subjective Effects

Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.

Physical Effects

• Spontaneous tactile sensations
• Increased heart rate
• Nausea
• Pupil dilation

Visual Effects

• Enhancements
• Colour enhancement
• Pattern recognition enhancement
• Visual acuity enhancement
• Distortions
• Drifting (melting, breathing, morphing, and flowing)
• Colour shifting
• Depth perception distortions
• Perspective distortions
• Symmetrical texture repetition
• Tracers
• After images
• Brightness alteration
• Diffraction
• Geometry
• Hallucinatory states
• Transformations
• Internal hallucination (autonomous entities; settings, sceneries, and landscapes; perspective hallucinations and scenarios and plots)

Cognitive Effects

• Conceptual thinking
• Cognitive euphoria
• Delusion
• Emotion enhancement
• Immersion enhancement
• Increased music appreciation
• Memory suppression
• Ego death
• Novelty enhancement
• Personal bias suppression
• Thought loops
• Time distortion
• Unity and interconnectedness

Auditory Effects

• Enhancements
• Distortions
• Hallucinations

Assessing Toxicity and Harm Potential

Long-term Health Effects

The long-term health effects and toxicity of recreational proscaline use remain largely unstudied within scientific contexts. Anecdotal evidence from the psychedelic community suggests minimal negative health repercussions associated with proscaline use. However, caution and harm reduction practices are strongly advised.

Understanding Tolerance and Addiction Potential

Proscaline is not deemed habit-forming, and the inclination to use it may diminish with continued consumption. Tolerance to proscaline's effects develops rapidly after ingestion, necessitating extended periods for tolerance reduction. Notably, proscaline induces cross-tolerance with other psychedelics, leading to diminished effects following consumption.

Legal Status

Global Regulations

• Germany: Controlled under the NpSG (New Psychoactive Substances Act) since November 26, 2016, with production, importation, administration, placement on the market, and trading deemed punishable offenses.
• Switzerland: Considered a controlled substance under specific regulations but legal for scientific or industrial purposes.
• United Kingdom: Classified as a Class A controlled substance under the phenethylamine derivatives clause of the Misuse of Drugs Act of 1971.
• United States: Currently uncontrolled.

Frequently Asked Questions (FAQ)

Q: What is proscaline?

A: Proscaline is a substituted phenethylamine psychedelic compound, structurally related to mescaline. It features two methoxy functional groups and an additional propyloxy group, contributing to its psychoactive effects.

Q: How does proscaline work?

A: Proscaline is believed to exert its psychedelic effects by interacting with the 5-HT2A receptor as a partial agonist, though the exact mechanisms remain incompletely understood.

Q: What are the subjective effects of proscaline?

A: Proscaline can induce a range of subjective effects, including enhanced sensory perception, visual distortions, cognitive euphoria, ego dissolution, time distortion, and auditory enhancements.

Q: Is proscaline safe to use?

A: The long-term health effects and toxicity of proscaline have not been extensively studied. While anecdotal reports suggest minimal negative health effects, caution and harm reduction practices are strongly recommended.

Q: Can I develop tolerance or addiction to proscaline?

A: Proscaline is not considered habit-forming, and tolerance typically develops rapidly after ingestion. However, it presents cross-tolerance with other psychedelics, leading to reduced effects following consumption.

Q: What is the legal status of proscaline?

A: The legal status of proscaline varies by country. For example, it is controlled in Germany under the NpSG, classified as a controlled substance in Switzerland, and considered uncontrolled in the United States.