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Table of Contents

1. Chemistry and Pharmacology of 2,4,5-Trimethoxyamphetamine (TMA-2)
2. Dosage Guidelines for TMA-2
3. Subjective Effects of TMA-2
4. Toxicity and Harm Potential of TMA-2
5. Tolerance and Addiction Potential of TMA-2
6. Legal Status of TMA-2

Overview of 2,4,5-Trimethoxyamphetamine (TMA-2)

2,4,5-Trimethoxyamphetamine (abbreviated TMA-2) is a synthetic psychedelic amphetamine known for producing a unique range of hallucinogenic and stimulant effects. These effects differ substantially from those of other psychoactive phenethylamines. TMA-2, along with TMA-6 and others, belongs to the trimethoxylated family of phenethylamines. Members of this family are noted for their complex mixture of hallucinogenic, stimulant, psychedelic, and entactogenic effects, distinguishing them from other psychedelic phenethylamine compounds like those in the 2C-x or DOx series.

Historical Background

Early Synthesis and Research

TMA-2 was first synthesized by Viktor Bruckner in 1933. However, it was not investigated as a psychoactive chemical until Alexander Shulgin synthesized and tested it in 1962. Shulgin published his synthesis and initial research findings in a 1964 paper, describing the effects as similar to mescaline but with fewer color effects, less nausea, and a tendency to cause anxiety and restlessness.

Counter-Culture References

In the early 1970s, there were occasional references to the use of TMA-2 in counter-culture publications. These sources described the drug as rarely produced for sale and expensive compared to LSD. This suggests that human usage of TMA-2 was very limited between its invention and the publication of its synthesis and pharmacology in Shulgin's 1991 book "PiHKAL" (Phenethylamines I Have Known And Loved).

Subjective Effects and Anecdotal Reports

Effects Profile

TMA-2 is known for its lack of classic psychedelic visuals compared to its parent compound, mescaline. Instead, it is recognized for its unique stimulating body-high and altered headspace, which can range from euphoric to dysphoric. Anecdotal reports suggest that TMA-2 is highly unpredictable and dose-sensitive, often producing uncomfortable body load, nausea, overstimulation, and inconsistent experiences between uses.

Modern Usage

Today, TMA-2 is used as an obscure recreational drug and an occasional entheogen. It is rarely sold on the streets and is almost exclusively available as a grey area research chemical through online vendors.

TMA-2 stands out among psychedelic amphetamines due to its unique effects and limited availability. Its unpredictable nature and dose sensitivity make it a substance of interest primarily to those in the psychedelics community who seek novelty and are aware of its potential for both positive and negative experiences.

Chemistry and Pharmacology of 2,4,5-Trimethoxyamphetamine (TMA-2)

Chemistry

2,4,5-Trimethoxyamphetamine (TMA-2) is a molecule within the substituted amphetamine class. Amphetamines are a subset of phenethylamines, which consist of a phenyl ring bonded to an amino (NH2) group via an ethyl chain, and a methyl group attached to the alpha carbon (Rα). The chemical structure of TMA-2 includes methoxy functional groups (CH3O-) attached to the second (R2), fourth (R4), and fifth (R5) carbons of the amphetamine backbone.

Pharmacology

TMA-2's psychedelic effects are primarily attributed to its action as a partial agonist at the 5-HT2A receptor. This receptor interaction is crucial in the modulation of neurotransmission that leads to psychedelic experiences. However, the precise mechanisms through which TMA-2 induces its effects remain not fully understood. The role of these receptor interactions and their contribution to the overall psychedelic experience continues to be a subject of ongoing research.

Dosage Guidelines for 2,4,5-Trimethoxyamphetamine (TMA-2)

Threshold Dosage

• Threshold: 5 mg
  At this dosage level, users may begin to feel the initial effects of TMA-2. This is considered the minimal effective dose where subtle changes in perception and mood might be noticeable.

Light Dosage

• Light: 10 - 20 mg
  A light dose of TMA-2 typically results in mild psychoactive effects. Users might experience slight alterations in sensory perception, mood enhancement, and minor stimulation without significant visual or cognitive changes.

Common Dosage

• Common: 20 - 40 mg
  The common dosage range for TMA-2 induces more pronounced psychoactive effects. Users often report noticeable changes in sensory perception, moderate stimulation, and an altered headspace. This dose is generally sufficient to produce the characteristic hallucinogenic and stimulant effects of TMA-2.

Strong Dosage

• Strong: 40 - 60 mg
  A strong dose of TMA-2 results in intense psychoactive effects. Users can expect significant alterations in sensory perception, heightened stimulation, and a deeply altered mental state. At this level, the effects can be overwhelming for some, and the risk of adverse reactions increases.

Heavy Dosage

• Heavy: 60 mg +
  Dosages above 60 mg are considered heavy and can lead to profound and potentially disorienting experiences. Users may experience powerful hallucinogenic effects, extreme stimulation, and a high likelihood of negative side effects such as anxiety, nausea, and body load. This dosage range is generally not recommended for most users due to the increased risk of unpredictable and intense reactions.

Subjective Effects of 2,4,5-Trimethoxyamphetamine (TMA-2)

Overview

The following section outlines the subjective effects of 2,4,5-Trimethoxyamphetamine (TMA-2), based on anecdotal user reports and analyses from PsychonautWiki contributors. These effects are compiled in the Subjective Effect Index (SEI), an open research literature. It is important to approach this information with a healthy degree of skepticism, as individual experiences can vary widely. Higher doses are more likely to induce the full spectrum of effects, but also increase the risk of adverse reactions, including addiction, severe injury, or death.

Physical Effects

• Stimulation: TMA-2 is typically extremely stimulating, promoting physical activities such as moving, running, dancing, and climbing. Users may experience shakiness and unsteadiness of the hands. This contrasts with the generally sedating effects of other psychedelics like psilocin.
• Spontaneous Bodily Sensations: Users often report a somewhat intense "body high" described as a mild, energetic pins-and-needles sensation that covers the entire body. This sensation may shift and travel in waves.
• Tactile Enhancement: Enhanced tactile sensations are consistently present at moderate doses.
• Nausea: Users may experience mild to extreme nausea at moderate to high doses, which usually subsides after vomiting or as the peak effects set in.
• Vasoconstriction: Typically occurring at higher doses, this effect can be particularly uncomfortable.
• Other Effects: Bodily control enhancement, pupil dilation, and increased blood pressure.

Visual Effects

• Enhancements:
  • Visual Acuity Enhancement
  • Color Enhancement
  • Pattern Recognition Enhancement
• Distortions:
  • Drifting (Melting, Flowing, Breathing, Morphing): These effects are detailed, slow, smooth, static in appearance, and often cartoon-like.
  • Tracers
  • After Images
  • Symmetrical Texture Repetition
  • Color Shifting
  • Diffraction

Cognitive Effects

• Empathy, Affection, and Sociability Enhancement: These effects are more pronounced in social settings, though they are weaker compared to substances like MDMA and 2C-B.
• Analysis Enhancement
• Thought Acceleration
• Time Distortion
• Novelty Enhancement
• Immersion Enhancement
• Conceptual Thinking
• Thought Connectivity
• Emotion Enhancement
• Increased Music Appreciation
• Personal Bias Suppression
• Memory Suppression
• Ego Death
• Wakefulness
• Increased Libido

Auditory Effects

• Enhancements: Users may experience enhanced auditory perception.
• Distortions and Hallucinations: Auditory distortions and hallucinations can also occur, although they are less common.

Experience Reports

Anecdotal reports describing the effects of TMA-2 can be found in various online resources, such as the Erowid Experience Vaults.

Toxicity and Harm Potential

Toxicity studies in rats have shown that TMA-2 doses of 80 mg/kg can induce frequent clonic convulsions, and a dose of 120 mg/kg has been associated with fatal toxic effects. The estimated LD50 in mice is 180 mg/kg. The long-term health effects and exact toxic dose of TMA-2 in humans are not well-studied due to its limited history of use. Anecdotal evidence suggests no significant negative health effects at low to moderate doses when used sparingly, but independent research is recommended before combining TMA-2 with other substances.

Tolerance and Addiction Potential

TMA-2 is not habit-forming, and the desire to use it typically decreases with use. Tolerance to its effects builds almost immediately after ingestion, with tolerance levels halving after three days and returning to baseline after seven days without further consumption. TMA-2 presents cross-tolerance with all psychedelics, reducing the effects of other psychedelics after its use.

Legal Status

• European Union: In November 2003, the European Council decided that TMA-2 should be subject to control measures and criminal penalties.
• Austria: TMA-2 is illegal to possess, produce, and sell under the SMG (Suchtmittelgesetz Österreich).
• Germany: Controlled under Anlage I BtMG (Narcotics Act, Schedule I) since October 10, 1999. It is illegal to manufacture, possess, import, export, buy, sell, procure, or dispense without a license.
• Switzerland: TMA-2 is specifically named as a controlled substance under Verzeichnis D.
• Turkey: Classified as a drug, making it illegal to possess, produce, supply, or import.
• United Kingdom: TMA-2 is a controlled Class A drug under the Misuse of Drugs Act 1977, covered by the generic definition (as a positional isomer of the UN controlled drug TMA).

Frequently Asked Questions (FAQ) about 2,4,5-Trimethoxyamphetamine (TMA-2)

Q: What is TMA-2?

A: TMA-2, or 2,4,5-trimethoxyamphetamine, is a synthetic psychedelic amphetamine known for producing a unique range of hallucinogenic and stimulant effects.

Q: How does TMA-2 differ from other psychedelic phenethylamines?

A: TMA-2 belongs to the trimethoxylated family of phenethylamines, which includes compounds like TMA-6. These substances produce a complex mixture of hallucinogenic, stimulant, psychedelic, and entactogenic effects that distinguish them from other psychedelic phenethylamines like those in the 2C-x or DOx series.

Q: What are the common dosage ranges for TMA-2?

A: The dosage ranges for TMA-2 are as follows:

• Threshold: 5 mg
• Light: 10 - 20 mg
• Common: 20 - 40 mg
• Strong: 40 - 60 mg
• Heavy: 60 mg +

Q: What are some of the subjective effects of TMA-2?

A: Subjective effects of TMA-2 include stimulation, spontaneous bodily sensations, tactile enhancement, nausea, vasoconstriction, visual enhancements and distortions, cognitive enhancements, auditory effects, and more.

Q: Is TMA-2 toxic or habit-forming?

A: TMA-2 can be toxic at higher doses, with reported instances of convulsions and fatal effects in animal studies. However, it is not considered habit-forming, and tolerance to its effects builds almost immediately after ingestion.

Q: What is the legal status of TMA-2?

A: The legal status of TMA-2 varies by country, with some countries classifying it as a controlled substance and others having specific regulations regarding its possession, production, sale, and use.