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Table of Contents
- Introduction
- Chemistry
- Pharmacology
- Dosage
- Subjective Effects
- Toxicity and Harm Potential
- Tolerance and Addiction Potential
- Dangerous Interactions
- Legal Status
- FAQ
3C-E: The Synthetic Psychedelic Compound
Understanding 3,5-Dimethoxy-4-ethoxyamphetamine
3,5-Dimethoxy-4-ethoxyamphetamine, commonly known as 3C-E or 3C-Escaline, represents a synthetic psychedelic compound within the amphetamine chemical class. Despite its name hinting at a potential relation to the 2C-x family, it diverges significantly. Instead, 3C-E bears the structural resemblance to escaline, a mescaline analogue, with an additional carbon atom, thereby categorizing it as a substituted amphetamine.
Historical Synthesis
Attributed to the pioneering work of Alexander Shulgin, 3C-E presumably emerged for the first time and gained recognition upon its publication in his influential book PiHKAL in 1991.
Current Applications and Distribution
Presently, 3C-E finds utilization in both recreational and research domains. It is primarily circulated through online vendors under a gray area classification as a research chemical. However, its distribution and consumption remain largely limited, and regulatory frameworks may vary across jurisdictions.
Effects and Knowledge Gaps
Despite its presence in recreational and research spheres, comprehensive understanding of 3C-E's effects remains elusive. Anecdotal reports suggest the presence of a robust body high accompanied by relatively subdued visual effects. However, empirical data and formal research regarding its pharmacological profile, long-term effects, and safety considerations are notably sparse. As such, further investigation into the properties and consequences of 3C-E use is warranted to inform responsible practices and potential therapeutic applications.
Chemistry
Understanding the Molecular Structure of 3C-E
3C-E, scientifically known as 3,5-Dimethoxy-4-ethoxyamphetamine, belongs to the substituted amphetamine class of molecules. Amphetamines are phenethylamines characterized by a phenyl ring connected to an amino (NH2) group via an ethyl chain, with a methyl group attached to the alpha carbon Rα. In the case of 3C-E, it features methoxy functional groups (OCH3) linked to carbons R3 and R5, along with an ethoxy chain (OCH2CH3) attached to carbon R4 of the phenyl ring.
3C-E stands as the amphetamine analog of escaline.
Pharmacology
Exploring the Pharmacological Characteristics of 3C-E
Despite its nomenclature potentially suggesting an association with the 2C-x family, 3C-E diverges significantly. It is, in fact, the 3-Carbon analog of escaline, hence its name.
The pharmacological profile of 3C-E suggests a strong affinity for 5-HT2A receptors. This affinity raises the possibility of its efficacy in potentially alleviating cluster headaches or mitigating the psychological distress linked to end-stage cancer.
The psychedelic effects induced by 3C-E are purportedly mediated by its interaction with the 5-HT2A receptor as a partial agonist. Nonetheless, the precise mechanisms through which these interactions culminate in the psychedelic experience remain largely undisclosed.
Dosage
Understanding the Recommended Dosage Ranges for 3C-E
When considering the consumption of 3C-E, it's crucial to adhere to recommended dosage guidelines to mitigate potential risks and ensure a safe experience.
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Threshold: The threshold dose for 3C-E is typically around 20 mg. At this dosage level, effects may begin to manifest, albeit subtly.
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Light: Light doses of 3C-E typically range between 30 to 40 mg. At this level, users may experience mild to moderate effects, which are discernible but not overwhelming.
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Common: A common dose of 3C-E falls within the range of 40 to 60 mg. At this dosage, users can anticipate a moderate psychedelic experience characterized by intensified sensory perception and altered cognition.
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Strong: Strong doses of 3C-E typically range from 60 to 80 mg. At this level, users may encounter profound psychedelic effects, including vivid visuals, altered sense of self, and profound introspection.
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Heavy: Heavy doses of 3C-E exceed 80 mg and may vary significantly depending on individual tolerance and sensitivity. At this dosage level, users should exercise caution as the intensity of effects can be overwhelming, potentially leading to challenging experiences.
Subjective Effects
Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.
It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.
Physical Effects
- Stimulation: 3C-E is typically considered to be moderately to extremely stimulating, contrasting with more sedating psychedelics such as psilocin.
- Spontaneous Physical Sensations: The "body high" of 3C-E is often described as somewhat intense, resembling a mild energetic pins and needles sensation enveloping the entire body.
- Physical Euphoria: While not reliably inducible, some users may experience feelings of physical euphoria, although discomfort can also manifest without apparent cause.
- Bodily Control Enhancement
- Tactile Enhancement: Enhanced tactile sensations are commonly reported at low to moderate levels.
- Nausea
- Increased Blood Pressure
- Increased Heart Rate
- Appetite Suppression
- Increased Perspiration
- Muscle Contractions
- Muscle Spasms
- Difficulty Urinating
- Dehydration
- Dry Mouth
- Temperature Regulation Suppression
- Diarrhea
- Teeth Grinding
- Pupil Dilation
- Increased Salivation
- Vasoconstriction
- Seizure: While rare, individuals predisposed to seizures may be at risk, particularly under physically taxing conditions such as dehydration, undernourishment, overheating, or fatigue.
Visual Effects
- Enhancements
- Visual Acuity Enhancement
- Color Enhancement
- Pattern Recognition Enhancement
- Distortions
- Drifting (Melting, Flowing, Breathing, and Morphing)
- Color Shifting
- Depth Perception Distortions
- Perspective Distortions
- Symmetrical Texture Repetition
- Tracers
- After Images
- Brightness Alteration
- Diffraction
- Geometry: The visual geometry of 3C-E is often likened to that of DOC or mescaline, characterized by intricate complexity, abstract form, and bright, multicolored scheme.
Hallucinatory States
- Transformations
- Internal Hallucination: Internal hallucinations are markedly prevalent with 3C-E, particularly in dark environments. They often exhibit lucid believability and are diverse in content, ranging from personal experiences to surreal or transcendental themes.
Cognitive Effects
- Conceptual Thinking
- Confusion: Higher doses may increase the likelihood of confusion.
- Thought Acceleration
- Thought Connectivity
- Anxiety & Paranoia: More common at higher doses, particularly when set and setting are not optimized. Cannabis use may exacerbate these effects.
- Empathy, Affection, and Sociability Enhancement: Typically observed in social settings at lower, non-impairing doses, albeit less pronounced than substances like MDMA.
- Cognitive Euphoria
- Analysis Enhancement
- Personal Bias Suppression
- Novelty Enhancement
- Immersion Enhancement
- Emotion Enhancement
- Increased Music Appreciation
- Increased Sense of Humor
- Laughter Fits
- Memory Suppression
- Ego Death
- Increased Libido
- Time Distortion
- Wakefulness
Auditory Effects
- Enhancements
- Distortions
- Hallucinations
Multi-sensory Effects
- Synaesthesia: A rare and non-reproducible effect, more likely at higher doses or among predisposed individuals.
Transpersonal Effects
- Existential Self-Realization
- Unity and Interconnectedness
Toxicity and Harm Potential
The toxicity and long-term health effects of recreational 3C-E use remain largely unstudied in scientific contexts due to its status as a research chemical. Anecdotal evidence suggests minimal negative health effects at low to moderate doses used sparingly, though caution and harm reduction practices are advised.
Tolerance and Addiction Potential
3C-E is not considered habit-forming, with diminished desire for continued use often reported over time. Tolerance to its effects develops rapidly and presents cross-tolerance with other psychedelics.
Dangerous Interactions
- Lithium
- Cannabis
- Stimulants
- Tramadol
Legal Status
- Germany: Controlled under the NpSG as of November 26, 2016.
- Japan: Controlled substance effective March 25th, 2015.
- Switzerland: Considered controlled unless for scientific or industrial use.
- United Kingdom: Illegal under the Psychoactive Substance Act.
- United States: Not scheduled, but may be considered a Schedule I drug under the Federal Analogue Act.
FAQ (Frequently Asked Questions)
Q: What is 3C-E?
A: 3C-E, or 3,5-Dimethoxy-4-ethoxyamphetamine, is a synthetic psychedelic compound belonging to the substituted amphetamine class.
Q: Is 3C-E related to the 2C-x family?
A: Despite its name suggesting a potential relation, 3C-E is actually the 3-carbon analog of escaline, not a member of the 2C-x family.
Q: What are the common effects of 3C-E?
A: Common effects include stimulation, visual distortions, altered thinking, and potential hallucinations.
Q: Is 3C-E safe to use?
A: The safety of 3C-E has not been extensively studied. Anecdotal evidence suggests minimal negative effects at low to moderate doses used sparingly, but caution and harm reduction practices are advised.
Q: Is 3C-E addictive?
A: 3C-E is not considered habit-forming, and the desire for continued use often diminishes over time.
Q: What are the legal implications of using 3C-E?
A: Legal status varies by country. For example, it is illegal in the United Kingdom and controlled in Germany and Japan.
Q: What precautions should be taken when using 3C-E?
A: Users should adhere to recommended dosage guidelines, practice harm reduction, and avoid dangerous interactions with other substances, such as lithium or cannabis.
Q: Are there any known dangerous interactions with 3C-E?
A: Yes, interactions with substances like lithium, cannabis, stimulants, and tramadol can increase the risk of adverse effects and should be approached with caution.
To prepare the content, the following materials were used:
- FDA Substance Registration System
- Hazardous Substances Data Bank. National Library of Medicine. 28 August 2008. Retrieved 22 August 2014. 3,4-Methylenedioxymethamphetamine
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